This product has been developed primarily for use in the areas of neuroprotection and neurodegenerative disease. PBI-04711 is a first-generation cardiac glycoside-free extract containing a unique mixture of oleander-derived triterpenes but no cardiac glycosides, meaning it does not contain oleandrin.
PBI-04711 has demonstrated surprisingly strong potential for neuroprotection. Experimental data obtained with PBI-04711 led to the development of PBI-01011.
Figure above shows PBI compound protection against neurodegeneration induced by oxygen-glucose deprivation in a brain slice model. See: J Neurochem. 2011 Nov;119(4):805-14. PMID: 21950737