“The Botanical Drug PBI-05204, a Supercritical CO2 extract of Nerium oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma”

Colapietro Alessandro, Yang Peiying, Rossetti Alessandra, Mancini Andrea, Vitale Flora, Chakraborty Sharmistha, Martelluci Stefano, Marampon Francesco, Mattei Vincenzo, Gravina Giovanni Luca, Iorio Roberto, Newman Robert A., Festuccia Claudio. Frontiers in Pharmacology, 23 March 2022.
Glioblastoma multiform (GBM) is the most common type of brain cancer. Despite intense therapeutic efforts, patient survival is low indicating the need for new therapeutic strategies. The research in this article demonstrates that not only does PBI-05204 work well against human glioblastoma using cell culture and animal models of GBM, but the therapeutic result is enhanced with the addition of radiotherapy. Mechanistic reasons for this synergy are presented in the article.