Priyankar Dey, Nisha Tewari, Somit Dutta, Robert A. Newman, Tapas Kumar Chaudhuri
Journal of Ethnopharmacology, Volume 323, 2024, 117717, ISSN 0378-8741
Oleander attenuates hepatic inflammation in a TLR4-independent manner and by favorable modulation of hepatocellular global metabolome that supports cytoprotection
Nerium oleander (NO) has been traditionally used in medicinal systems across the globe to treat liver-associated chronic metabolic diseases. This article reports the results of an investigation into the cellular mechanisms involved in the hepatoprotective effects of a non-toxic dose of oleander. NO reduced systemic inflammation, serum lipid peroxidation byproducts, and glucose levels while also attenuating inflammation-induced loss of antioxidant enzyme activities. Importantly, the research found that NO favorably modulates the intracellular global metabolome (key metabolic pathways) that support cytoprotective activities.