Efficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health

Newman, R. A., Chase, C. C. L., Matos, J. R., Abdelsalam, K., Buterbaugh, R., Van Holland, S., Abdelaal, H., Woolum, A., & Jagannadha Sastry, K. Antiviral Chemistry and Chemotherapy, 24 May 2022.

Bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), and bovine coronavirus (BCV) threaten the productivity of cattle worldwide. Development of therapeutics that can control the spread of these viruses is an unmet need. The present research was designed to explore the in vitro antiviral activity of the Nerium oleander derived cardiac glycoside oleandrin and a defined N. oleander plant extract (PBI-05204) containing oleandrin.

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