Because the active principle ingredient in PBI-05204 readily crosses the blood brain barrier (BBB) it has the potential to benefit malignant disease that resides in the brain.
PBI has initiated research on pediatric glioblastoma multiforma (GBM) together with Dr. Xiao-Nan Li (Brain Tumor Program, Texas Children’s Cancer Center, Baylor College of Medicine) and Dr. Peiying Yang (Univ. Texas M. D. Anderson Cancer Center). Initial preclinical research with PBI-05204 against human GBM growing in vitro as well as in murine brain tissue has been very encouraging. There are few, if any, current effective drugs available for treatment of pediatric GBM.