“Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2″

 Kenneth S.Plante, Varun Dwivedi, Jessica A.Plante, DianaFernandez, Divya Mirchandani, Nathen Bopp, Patricia V. Aguilar, Jun-Gyu Park, Paula Pino Tamayo, Jennifer Delgado, Vinay Shivanna, Jordi B. Torrelles, Luis Martinez-Sobrido, Rick Matos, Scott C. Weaver, K. Jagannadha Sastry, Robert A.Newman. Biomedicine & Pharmacotherapy.
With continued expansion of COVID-19 caused by the severe respiratory syndrome 2 (SARS-CoV-2) antiviral therapies as well as effective vaccines are desperately needed. This article presents evidence for the significant inhibition of SARS-CoV-2 by oleandrin and the company’s experimental product PBI-06150. The potent prophylactic and therapeutic antiviral activities together with initial evidence of the safety and efficacy of PBI-06150 in a relevant hamster model of COVID-19 support further development of PBI’s antiviral products against SARS-CoV-2 as well as other viruses that threaten human health and well being.