Testing of PBI-05204 at Duke University has shown that components within the product other than cardiac glycosides might contribute to protection against certain neurodegenerative diseases. PBI-04711 has been derived from a subfractionation of PBI-05204 and it has surprisingly shown a strong potential for neuroprotection even without any cardiac glycoside components. Extensive analytical research is now ongoing to carefully define qualitatively and quantitatively the exact active ingredients in this new product.
Figure above shows PBI compound protection against neurodegeneration induced by oxygen-glucose deprivation in a brain slice model. See: J Neurochem. 2011 Nov;119(4):805-14. PMID: 21950737