1. Is oleandrin Safe?
Yes. Oleandrin is a unique compound of an extract of the common Nerium oleander plant and is the main ingredient in a dietary supplement proposed by Phoenix Biotechnology. Similar plant extracts of the Nerium oleander plant have been used in Phase I and Phase II clinical trials in that successfully established the pharmacokinetics (an effective and safe dosage rate) of oleandrin.
2. I’ve read that the Oleander plant is poisonous. What is the difference between the Oleander plant and oleandrin?
The Nerium oleander plant is poisonous if leaves and stems are ingested by animals and humans. That said, there are many isolated plant substances that are important and effective when separated from the plant itself. For instance, a molecule in the Periwinkle flower provides an important treatment for cancer. The molecule, Taxol, is the most well-known natural-sourced cancer drug in the United States, which is derived from the bark of the Pacific yew tree. The molecule Oleandrin belongs to the class of compounds known as cardiac glycosides. Several peer-reviewed studies have shown that oleandrin, as well as other cardiac glycosides related to existing digitalis-like drugs, which are effective in guarding against congestive heart failure and have been found to have strong anti-viral properties.
The safe and proper isolation of oleandrin requires special knowledge and extraction techniques. Do not eat the oleander any parts of the oleander plant directly.
3. What are the side effects?
Our Oleandrin product is 1/16th the potency of the highest dose achieved in clinical trials before any side effects were observed. No side effects have been observed at this dosing level in any of our studies.
4. How many people have been given oleandrin?
Well over 1,000 people have safely received Oleandrin.
5. How do I take it?
For this product, the suggested serving size is 0.5ml under the tongue for one minute, every 6 hours. The product enters the body quickly and efficiently through sublingual absorption.
6. How long do I take it for?
Each vial contains approximately 7 days of servings. Some people will only require one vial while others may require more, depending on their situation.
7. How does oleandrin work?
Oleandrin has been shown to have strong antiviral activity against “enveloped” viruses such as Ebola, Marburg, HIV and HTLV-1, and SARS-CoV-2 (Covid-19), which is also an enveloped virus. Since being first described more than 60 years ago, the enzyme inside your cells called the Na+, K+-ATPase has been studied extensively. Cardiac glycosides’ like oleandrin not only inhibit the pump function of the Na+, K+-ATPase but also activate pathways inside cells, which are important in many biological processes. Recently, antiviral effects have been described as a unique feature of Na+, K+-ATPase inhibition with the use of cardiac glycosides. Cardiac glycosides have been shown to be effective against both DNA viruses such as cytomegalovirus and herpes simplex and RNA viruses such as influenza, chikungunya, coronavirus, and respiratory syncytial virus, among others. Consequently, cardiac glycosides have emerged as potential broad-spectrum antiviral drugs, with the great advantage of targeting cell host proteins, which help to minimize resistance to antiviral treatments, making them a very promising strategy against human viral infections. For more information on this, see: PMCID: PMC6121263. Another interesting paper was just published in July 2020 that models the ability of cardiac glycosides to inhibit the SARS-CoV-2 2-O-methyltransferase (2′OMTase), which plays a key role in methylation of viral RNA for evading host immune system, see: Life Sciences Journal Article.
8. Does Oleandrin work prophylactically?
A recent study in Vero cells at UTMB found prophylactic oleandrin administration at concentrations down to 50 nanograms exhibited potent antiviral activity.
9. What is it combined with to create the product oil?
Like CBD oil, this Oleander product is combined with Medium Chain Triglyceride (MCT) oil and natural flavoring. There are no artificial additives.
10. What about allergies to Orange, Coconut, or oleander?
It has been shown in several respected journals that coconut derived MCT oil should not cause allergies in those that have allergies to tree nuts. Coconut allergy itself is extremely rare. The oleandrin product is also flavored with natural blood orange flavor. Citrus allergies are also exceedingly rare; however, they do occur. The blood orange flavor is all natural and derived from blood orange and is made in the USA. If someone concerned with an allergy to this product, they should be cautioned and if they do wish to try the product, they should do so under a physician’s supervision as a food challenge.