Photomicrograph of a Nerium oleander leaf.
Nerium oleander cultivation.
Photomicrograph of human nerve cells.

Phoenix Biotechnology, Inc. (PBI)'s Focus

Phoenix Biotechnology, Inc., has been exploring the health-related benefits of a novel extract of Nerium oleander for the past 20 years. The company has developed a supercritical CO2 extraction of Nerium oleander into a new botanical drug – PBI-05204.

PBI-05204 is a ‘botanical drug’ that has been through initial FDA review and approved for the Phase I and Phase II clinical trials which were conducted in the United States. These trials have shown that this oral (capsule) formulation is safe for administration to patients without undue toxicity.

A distinction of PBI-05204 is that research has consistently proven that this drug crosses the blood brain barrier which opens up several potential applications. Extensive research has been done in the following areas: Antiviral, Cancer, and Neurodegenerative Diseases.


May, 2022
Efficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health". Antiviral Chemistry and Chemotherapy, 24 May 2022.
Bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV). and bovine coronavirus (BCV) threaten the productivity of cattle worldwide. Development of therapeutics that can control the spread of these viruses is an unmet need. The present research was designed to explore the in vitro antiviral activity of the Nerium oleander derived cardiac glycoside oleandrin and a defined N. oleander plant extract (PBI-05204) containing oleandrin.


March, 2022
The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma". Frontiers in Pharmacology, 23 March 2022.
Glioblastoma multiform (GBM) is the most common type of brain cancer. Despite intense therapeutic efforts, patient survival is low indicating the need for new therapeutic strategies. The research in this article demonstrates that not only does PBI-05204 work well against human glioblastoma using cell culture and animal models of GBM, but the therapeutic result is enhanced with the addition of radiotherapy. Mechanistic reasons for this synergy are presented in the article.