Photomicrograph of a Nerium oleander leaf.
Nerium oleander cultivation.
Photomicrograph of human nerve cells.

Phoenix Biotechnology, Inc. (PBI)'s Focus

Phoenix Biotechnology, Inc., has been exploring the health-related benefits of a novel extract of Nerium oleander for the past 20 years. The company has developed a supercritical CO2 extraction of Nerium oleander into a new botanical drug – PBI-05204.

PBI-05204 is a ‘botanical drug’ that has been through initial FDA review and approved for the Phase I and Phase II clinical trials which were conducted in the United States. These trials have shown that this oral (capsule) formulation is safe for administration to patients without undue toxicity.

A distinction of PBI-05204 is that research has consistently proven that this drug crosses the blood brain barrier which opens up several potential applications. Extensive research has been done in the following areas: Antiviral, Cancer, and Neurodegenerative Diseases.


March, 2021
Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2". Biomedicine & Pharmacotherapy.
With continued expansion of COVID-19 caused by the severe respiratory syndrome 2 (SARS-CoV-2) antiviral therapies as well as effective vaccines are desperately needed. This article presents evidence for the significant inhibition of SARS-CoV-2 by oleandrin and the company's experimental product PBI-06150. The potent prophylactic and therapeutic antiviral activities together with initial evidence of the safety and efficacy of PBI-06150 in a relevant hamster model of COVID-19 support further development of PBI's antiviral products against SARS-CoV-2 as well as other viruses that threaten human health and well being.


September, 2020
The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties". Colapietro Alessandro, Yang Peiying, Rossetti Alessandra, Mancini Andrea, Vitale Flora, Martellucci Stefano, Conway Tara L., Chakraborty Sharmistha, Marampon Francesco, Mattei Vincenzo, Gravina Giovanni Luca, Biordi Assunta Leda, Wei Daoyan, Newman Robert A., Festuccia Claudio. Frontiers in Pharmacology.